49ers vs. Titans: The best player prop bets for TNF

The Tennessee Titans will attempt to get back in the win column and retain their top-three seed in the AFC when they host the NFC’s sixth seed, the San Francisco 49ers, on Thursday Night Football in Week 16.

The Titans suffered their third loss in four games on Sunday, when they fell to the 7-6-1 Pittsburgh Steelers, 19-13, on the road.

Turnovers continued to trouble Tennessee, as the team committed four against Pittsburgh — including three on consecutive drives — all of which the Steelers converted into points.

Quarterback Ryan Tannehill threw for only 153 yards and recorded one touchdown on a one-yard run in the first quarter, while D’Onta Foreman ran for 108 of the team’s 201 rushing yards.

Tennessee won the time-of-possession battle (39:08) but went 1-of-4 on red zone opportunities.

The injury-riddled squad also lost veteran wideout Julio Jones to a hamstring injury in the second quarter and may be without left tackle Taylor Lewan on Thursday.

The Niners, on the other hand, are trending upward and won their fifth matchup in six games. 

Both the run game and defense were humming against the Atlanta Falcons in a 31-13 victory. Jimmy Garoppolo also turned in a steady performance, with 235 yards and a touchdown on 78.3% passing.

With all that in mind, let’s further examine the 49ers and Titans’ clash on Thursday Night Football, as we look at the three best player props to bet.

Jimmy Garoppolo Over/Under 236.5 passing yards

The Titans are ranked second in the league in rushing yards allowed (86.9), so Garoppolo will need to step up in the passing game to push the ball down the field.

The veteran QB has thrown for more than 237 yards in two of his past three games, including a pair of 290-yard performances against the Cincinnati Bengals and Seattle Seahawks.

Tennessee gives up 242.3 yards per contest (19th most in the league) and faces an average of 37.2 opponent pass attempts per game.

With San Francisco's backfield limited with Elijah Mitchell out with a knee injury, Garoppolo will be all the more critical to San Francisco's success on offense.

Pick: Over 236.5  passing yards (-115)

George Kittle Over/Under 68.5 receiving yards

One receiver Garoppolo will look to pass to is star tight end George Kittle, who has caught for 425 yards over his last three games.

In last Sunday's win over Atlanta, Kittle hauled in six passes for 93 yards, and he posted a 151-yard outing and 181-yard performance against Cincinnati and Seattle, respectively.

While Kittle has proven to be one of the most lethal players at his position, he'll confront a Titans defense that has surrendered the fourth fewest receiving yards (496) to tight ends this season.

Tennessee has allowed more than 60 yards to a tight end twice in 2021 — in Week 5 to Jaguars tight end Dan Arnold (64) and in Week 7 to Chiefs tight end Travis Kelce (65).

Look for Kittle to fall short of 69 or more receiving yards in Thursday's matchup.

Pick: Under 68.5 receiving yards (-114)

Deebo Samuel anytime touchdown scorer

While Kittle may have a quiet night against Tennessee, receiver Deebo Samuel should continue to wreak havoc in the Niners offense.

San Francisco's top receiver (1,088 yards) has demonstrated a new level of versatility this season, as he's rushed for a team-high seven scores to go along with his five receiving touchdowns.

Samuel has run for at least one touchdown in his last five games, including two against the Minnesota Vikings.

The Titans surrender an average of 2.4 touchdowns per contest, and one of those will go to Samuel on Thursday night. 

Pick: Deebo Samuel to score an anytime touchdown (+117)