The Los Angeles Chargers will look to get back in the win column when they travel to Philadelphia to face the Eagles on Sunday.

Let's examine this interconference matchup, beginning with the latest betting odds.

Mike Williams vital to Chargers' success

It has been somewhat of a breakout season for Mike Williams in the receiver’s fifth season. He is averaging career highs in both catches per game (five) and yards per game (73.9) through seven games this year.

However, the Chargers seem to live and die by his individual success. In the team’s four wins this season, Williams has averaged six catches for 95 yards and five total touchdowns.

In L.A.'s three losses, he has averaged 3.7 catches for 45.7 yards and one total touchdown.

The last two games have resulted in a total of four catches for 46 yards and no touchdowns for Williams.

The Eagles defense will provide some opportunity for Williams to get back into his groove.

Philadelphia has allowed deep threat wide receivers like Tyreek Hill and Antonio Brown to go off for monster games. Williams' biggest strength is getting open deep over the middle of the field, and that is also where the Eagles are the weakest defensively.

Will the real Eagles please stand up?

The Eagles have been a perplexing team all season long. They have a losing record of 3-5, yet they are +12 in points for, compared to points against.

They are ahead of the Chargers, Kansas City Chiefs, Pittsburgh Steelers, Cleveland Browns, and San Francisco 49ers in this department.

One major reason for this scoring disparity, despite the Eagles' losing record, is their bookend blowout victories this season over the Atlanta Falcons in Week 1 and the Detroit Lions last week. In both of those games, the Eagles utilized their run game with great success.

In the Eagles' three victories, they have averaged 33 rush attempts for 166.7 yards. In their five losses, they have averaged 22.2 rushes for only 110.6 yards.

The Chargers enter this game with the worst rushing defense in the league, allowing an average of 159.4 yards per game. The Eagles need to take advantage of this, no matter who is in the backfield.

Chargers and Eagles betting trends

• Chargers are 4-1 ATS in their last five road games
• Chargers are 0-7 ATS in their last seven games in November
• Eagles are 6-2 ATS in their last eight games as a home underdog
• The Over is 4-1 in the last five meetings
• The Over is 5-1 in the Chargers' last six games as a road favorite
• The Under is 14-2 in the Eagles' last 16 games in November

Game of mismatches

We discussed two big mismatches in this game, so which team will take advantage of its mismatch? It is difficult for me to trust Nick Sirianni to stick to the run game for the Eagles, given his track record this year.

I do feel comfortable believing that the Chargers' offensive coordinator, Joe Lombardi, will find openings for Mike Williams in the defensive matchups. Lombardi was excellent at getting big wideouts, like Marques Colston and Calvin Johnson, open throughout his career, and now he has Williams.

I like the Chargers to have the better gameplan and use their talent with more success than the Eagles. The Chargers will find themselves back in the mix of top AFC contenders after this big road win.

Score Prediction: Chargers 31, Eagles 22

NFL Week 9 picks: Chargers -2.5, Over 50.5

Chargers vs. Eagles pick powered by The Quant Edge

Our predictive engine is calling for the Chargers to win outright.