The Jacksonville Jaguars, coming off a massive upset, travel to Indianapolis to face the Colts on Sunday in an AFC South matchup.

Let's examine this divisional matchup, beginning with the latest betting odds.

Jacksonville shocked the world

After finding themselves at the bottom of almost every offensive and defensive stat category in the league, the Jaguars shocked the world on Sunday when they took down the Buffalo Bills as 16-point underdogs.

The Jags did it with defense, winning by an ugly score of 9-6. They were able to force three turnovers and sack Josh Allen four times. Their own Josh Allen (defensive end) had a career game with eight tackles, two tackles for loss, a sack, an interception, and a fumble recovery.

When they travel to Indianapolis on Sunday, the Jaguars will need to play with that same aggressiveness on defense to stand any chance at another upset. The Colts have won four of their last six, averaging 31.5 points per game. However, they have turned the ball over five times in the last three games, and Carson Wentz could struggle with Jacksonville's pass rush.

JT is rocking and rolling

Jonathan Taylor started this season a little slowly, but is up to top speed now. Taylor is averaging 108.3 rushing yards and 37.2 receiving yards over the past six games. His emergence in the offense is the main reason for the Colts’ recent success.

Carson Wentz gets a lot of heat from media and fans alike, but he is having an impressive season. He is averaging 244.2 passing yards per game and has a quarterback rating of 100.1. Wentz also has 17 touchdowns to only three interceptions.

The big issue for the Colts has been their inability to hold onto leads. They were up 14-0 over Tennessee two weeks ago before losing in OT. Five weeks ago on Monday Night Football, the Colts were up 25-9 in the fourth quarter against the Baltimore Ravens before also losing in OT. Even last week, they were up 42-10 on the Jets before allowing 20 points in less than 15 minutes of game time.

Jaguars and Colts betting trends

• The Jaguars are 0-4 ATS in their last four games following an ATS win
• The Colts are 4-0 ATS vs. teams with a losing record
• The Under is 7-1 in the Jaguars' last eight games as an underdog
• The Under is 5-1 in the Colts' last six games vs. AFC South opponents
• The Jaguars are 10-1-1 ATS in their last 12 meetings
• The Under is 8-2 in the last 10 meetings in Indianapolis

Colts will lean heavily on Taylor

Last year, the Colts were embarrassed in Week 1 with a loss in Jacksonville that ended up being the lone Jaguars win on the season. However, in the second game in Indianapolis, the Colts leaned heavily on Taylor as he ran for 253 yards and two touchdowns in a 14-point victory.

The Titans leaned heavily on Derrick Henry in their game against Jacksonville earlier this year and they won with ease, 37-19. The Colts will want to avoid the Jacksonville pass rush and not allow Wentz to find himself in situations in which he can make costly mistakes.

I like the Colts to impress in this one, just as they did against the Texans earlier this year.

Score prediction: Colts 31, Jaguars 10

NFL Week 10 picks: Colts -10.5, Under 47.5

Jaguars vs. Colts pick powered by The Quant Edge

Our predictive engine is calling for the Colts to win outright.